Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography

Significance: High density diffuse optical tomography (HD-DOT) as applied in functional near-infrared spectroscopy (fNIRS) is largely limited to continuous wave (CW) data. Using a single modulation frequency, frequency domain (FD) HD-DOT has recently demonstrated better localization of focal activation compared CW We show that combining and FD measurements multiple frequencies increases imaging performance fNIRS. Aim: evaluate the benefits frequencies, different well data fNIRS HD-DOT. Approach: A layered model was used, with occurring within cortex layer. were simulated at 78, 141, 203 MHz without noise. The error, full width half maximum, effective resolution evaluated. Results: Across average three metrics, 141 MHz, performed 8.4% than CW, combination 21.7% CW. 5% 78 MHz. Moreover, combined up 3.92% alone. Conclusions: offers alone, higher increasing accuracy. Combining yields best overall performance.